MedDataToolAciphex is a medication used to treat conditions like gastroesophageal reflux disease (GERD), duodenal ulcers, and to help eliminate a specific stomach bacteria called Helicobacter pylori. It works by reducing the amount of acid your stomach makes, which helps heal the esophagus and relieve heartburn. You typically take it as a delayed-release tablet, starting with a dose of 20 mg once daily, and it can be taken for up to 8 weeks depending on your condition. It's important to know that Aciphex should not be used if you are allergic to it or similar medications. Additionally, if you're taking rilpivirine, a medication used for HIV, you should avoid using Aciphex as it can interact with that drug.
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Uses
- Erosive or ulcerative gastroesophageal reflux disease (GERD).
- Symptomatic GERD.
- Duodenal ulcers.
- Helicobacter pylori infection.
- Pathological hypersecretory conditions.
- Short-term treatment of symptomatic GERD in adolescents 12 years and older.
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Dosage
- 20 mg once daily for healing of erosive or ulcerative GERD for 4 to 8 weeks. 20 mg once daily for maintenance of healing of erosive or ulcerative GERD. 20 mg once daily for symptomatic GERD in adults for up to 4 weeks. 20 mg once daily after morning meal for healing of duodenal ulcers for up to 4 weeks. 20 mg with amoxicillin and clarithromycin for 7 days for H. pylori eradication. 20 mg once daily for symptomatic GERD in adolescents for up to 8 weeks.
- Swallow tablets whole; do not chew or crush.
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Side effects
Common
painpharyngitisflatulenceinfectionconstipationIn adolescents: headachediarrheanauseavomitingabdominal painacute tubulointerstitial nephritisvitamin B-12 deficiencyhypomagnesemia
Serious
Clostridium difficile-associated diarrheabone fracturesevere skin reactions
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Warnings
⚠ Important warnings
- Not recommended for children under 12 years.
- Monitor for increased INR with warfarin.
- May cause serious kidney problems.
- Risk of Clostridium difficile-associated diarrhea.
- Potential for bone fractures.
- May cause vitamin B-12 deficiency.
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Drug interactions
- Warfarinincreased risk of bleedingMonitor
- Digoxinincreased exposure of digoxinCaution
- Methotrexatemay elevate methotrexate levelsCaution
- Clarithromycinserious adverse reactions possibleCaution
- Antiretroviralsvariable effects on drug levelsCaution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).