MedDataToolActoplus Met
Generic: Pioglitazone And Metformin Hydrochloride
Thiazolidinedione✓ FDA-verified
View full FDA label ↗Actoplus Met is a medication used to help adults with type 2 diabetes manage their blood sugar levels alongside diet and exercise. It combines two ingredients that improve how your body responds to insulin and helps lower the amount of sugar your liver makes. You take it as a tablet, usually once daily with meals, starting at a dose of 15 mg of pioglitazone and 850 mg of metformin, with a maximum of 45 mg and 2,550 mg respectively. It's important to know that this medication should not be used if you have severe heart failure or significant kidney problems. Additionally, if you're taking gemfibrozil, a cholesterol-lowering medication, the dose of Actoplus Met may need to be adjusted due to potential interactions.
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Uses
- Type 2 diabetes mellitus.
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Dosage
Take orally with meals to reduce gastrointestinal side effects.
Starting dose is individualized based on current regimen.
Maximum daily dose is 45 mg of pioglitazone and 2,550 mg of metformin.
Assess renal function before starting and periodically thereafter.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
upper respiratory tract infectionedemadiarrheaheadacheweight gain
Serious
congestive heart failurelactic acidosisurinary bladder tumors
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Warnings
⚠ Important warnings
- Not recommended for type 1 diabetes or diabetic ketoacidosis.
- Monitor for signs of heart failure after starting treatment.
- Discontinue if eGFR falls below 30 mL/min.
- Use caution in patients with liver disease.
- Not recommended in patients with symptomatic heart failure.
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Drug interactions
- Gemfibrozillimit dose to 15 mg/850 mg dailyCaution
- Rifampinmay decrease pioglitazone concentrationsCaution
- Carbonic anhydrase inhibitorsincrease risk of lactic acidosisCaution
- Cimetidinemay increase metformin accumulationCaution
- Insulinmay increase risk of hypoglycemia.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).