MedDataToolAcyclovir Sodium is a medication used to treat various herpes infections, including those affecting the skin and mucous membranes, herpes encephalitis, and shingles, particularly in patients with weakened immune systems. It works by stopping the growth of the virus that causes these infections. The medication is given through an intravenous infusion, usually starting at a dose of 5 mg per kilogram of body weight every 8 hours, with a maximum dose of 20 mg per kilogram every 8 hours not to be exceeded. It's important to know that this medication should only be given through an IV and not by other methods like injections or orally, as improper use can lead to serious kidney damage. Additionally, if you are taking probenecid, it can affect how acyclovir is processed in your body, so be sure to discuss this with your healthcare provider.
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Uses
- Herpes simplex infections in immunocompromised patients.
- Severe initial episodes of herpes genitalis.
- Herpes simplex encephalitis.
- Neonatal herpes simplex virus infection.
- Varicella-zoster infections in immunocompromised patients.
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Dosage
Adults and adolescents: 5 mg/kg infused over 1 hour, every 8 hours for 5-10 days depending on condition.
Pediatrics under 12 years: 10 mg/kg infused over 1 hour, every 8 hours for 7 days.
For herpes simplex encephalitis, adults: 10 mg/kg every 8 hours for 10 days.
Adjust doses for patients with renal impairment as needed.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
inflammation or phlebitis at injection sitenauseavomitingitchingrash
Serious
renal failureanaphylaxisseizuresconfusionhallucinations
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Warnings
⚠ Important warnings
- Only for intravenous infusion; avoid other routes.
- Rapid infusion may cause renal damage.
- Renal failure has been reported, sometimes leading to death.
- TTP/HUS has occurred in immunocompromised patients.
- Use caution in elderly patients with renal impairment.
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Drug interactions
- Probenecidincreases acyclovir levels and half-life.Monitor
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).