Additive Formula 3

Generic: Dextrose Monohydrate, Trisodium Citrate Dihydrate, Sodium Chloride, Sodium Phosphate, Monobasic, Monohydrate, Citric Acid Monohydrate, And Adenine

Rx only

Additive solution✓ FDA-verified

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Additive Formula 3 is a solution used to help preserve red blood cells collected during a specific blood donation process called apheresis. It works by providing nutrients and maintaining the right conditions for the red blood cells so they can be stored longer before being given to patients. The solution is added to the blood collection tubing after the donation is complete, and the exact amount used is determined by the blood collection device. It’s important to know that this solution should never be infused directly into the donor. Additionally, patients receiving blood products containing this solution should be monitored for signs of citrate toxicity, which can cause symptoms like tingling or low blood pressure.

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Uses

Used with Trima Accel red blood cell (RBC) apheresis collections.

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Dosage

AS-3 is added after RBC collection is complete.

For automated procedures, the device determines the dose.

For manual procedures, refer to the operator's manual for dosing.

Always connect AS-3 after the donor is disconnected.

Always follow your doctor's specific instructions for your dose.

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Side effects

Common

Mild: Tingling sensation around the mouth or extremities

Serious

Hypotension and possible cardiac arrhythmia

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Warnings

⚠ Important warnings

Monitor for citrate toxicity signs in blood recipients.
Citrate toxicity may occur more in patients with low calcium levels.

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Answers pulled from the FDA label only.

Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).