Aloprim is a medication used to help manage high levels of uric acid in patients with certain types of cancer, like leukemia and lymphoma, especially when they cannot take oral medications. It works by blocking the production of uric acid in the body, which helps prevent complications related to high uric acid levels. The medication is given through an intravenous infusion, starting at a dose of 200 mg per square meter of body surface area each day, and can go up to a maximum of 400 mg per square meter daily. It's important to know that Aloprim should not be used if you have had a severe allergic reaction to allopurinol, its active ingredient. Additionally, if you are taking medications like mercaptopurine or azathioprine, be cautious, as Aloprim can increase their effects and potentially lead to serious side effects.
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Uses
- Leukemia.
- Lymphoma.
- Solid tumor malignancies.
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Dosage
Adults: 200 mg/m² to 400 mg/m² per day.
Maximum: 600 mg per day.
Pediatric patients: Starting dose 200 mg/m² per day, maximum 400 mg per day.
Administer 24 to 48 hours before chemotherapy.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
skin rashnauseavomitinghypersensitivity reactions
Serious
renal failurerenal impairmenthepatotoxicitymyelosuppressiondrowsiness
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Warnings
⚠ Important warnings
- Risk of severe skin rash and hypersensitivity.
- Renal function impairment may occur.
- Hepatotoxicity can happen.
- Myelosuppression may occur.
- Use caution with thiazide diuretics.
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Drug interactions
- Capecitabinemay decrease effectivenessCaution
- Pegloticaserisk of anaphylaxisCaution
- Mercaptopurineincreases risk of adverse reactionsMonitor
- Azathioprineincreases risk of adverse reactionsMonitor
- Theophyllinemay decrease clearanceCaution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
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