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Amitriptyline

Generic: Amitriptyline Hydrochloride

Rx only
Tricyclic antidepressant✓ FDA-verified
View full FDA label ↗
Amitriptyline is a medication used to help relieve symptoms of depression. It works by affecting certain chemicals in the brain that help regulate mood. You typically take it by mouth, starting with a low dose of 75 mg per day, which can be increased to a maximum of 150 mg per day if needed. It's important to know that this medication can increase the risk of worsening depression or suicidal thoughts, especially in younger patients. Additionally, you should not take amitriptyline if you are currently using monoamine oxidase inhibitors (MAOIs), as this can lead to serious side effects.
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Uses

  • Symptoms of depression.
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Dosage

Start with 75 mg per day for adults, divided into doses.
May increase to 150 mg per day if needed.
For some, starting with 50 to 100 mg at bedtime is effective.
Hospitalized patients may start at 100 mg per day, increasing to 200 mg if necessary.
Lower doses are recommended for adolescents and elderly patients.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

Drowsinessdizzinessfatigueheadachedry mouthComa

Serious

seizureshallucinationsheart problemssuicidal thoughts
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Warnings

⚠ Important warnings

  • Risk of worsening depression and suicidality in all ages.
  • Not approved for use in children under 12 years.
  • Use caution in patients with a history of seizures.
  • May block the effects of certain blood pressure medications.
  • Monitor closely for unusual behavior changes.
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Drug interactions

  • Topiramatemay increase amitriptyline levelsCaution
  • Cimetidineincreases amitriptyline levels and side effectsMonitor
  • Alcoholenhances sedative effectsCaution
  • Disulfirammay cause delirium when combinedCaution
  • Anticholinergic drugsmay increase side effects.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).