MedDataToolAntara is a medication used to help lower high triglyceride levels in adults with severe hypertriglyceridemia and to reduce bad cholesterol when other treatments aren't suitable. It works by helping the body break down fats more effectively. You take it as a capsule, usually once a day, starting with a dose of 30 mg or 90 mg, depending on your condition, and the maximum dose is 90 mg daily. It's important to know that Antara should not be used by people with severe kidney problems or active liver disease. Additionally, if you're taking blood thinners like coumarin anticoagulants, be aware that Antara can increase your risk of bleeding.
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Uses
- Severe hypertriglyceridemia (TG ≥ 500 mg/dL).
- Primary hyperlipidemia when LDL-C lowering therapy is not possible.
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Dosage
30 mg to 90 mg orally once daily for severe hypertriglyceridemia. 90 mg orally once daily for primary hyperlipidemia.
Take as a single dose at any time of day, with or without food.
Assess triglyceride levels 4 to 8 weeks after starting treatment.
Discontinue if no adequate response after two months.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Increased AST and ALT levelsIncreased CPKAbdominal painPancreatitis
Serious
Abnormal liver testsMyopathy and rhabdomyolysis
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Warnings
⚠ Important warnings
- May increase risk of pancreatitis with very high triglycerides (> 2000 mg/dL).
- Not proven to reduce heart disease risk in diabetes patients.
- Contraindicated in severe renal impairment.
- Monitor liver function tests regularly.
- Use caution with anticoagulants and immunosuppressants.
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Drug interactions
- Statinsincreased risk of myopathy and rhabdomyolysisMonitor
- Colchicineincreased risk of myopathy and rhabdomyolysisMonitor
- Coumarin anticoagulantsmay prolong PT/INRCaution
- Immunosuppressantsrisk of kidney problemsCaution
- Bile-acid binding resinstake Antara at specific times to avoid absorption issuesAvoid
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).