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Aristada Initio

Generic: Aripiprazole Lauroxil

Rx only
Antipsychotic✓ FDA-verified
View full FDA label ↗
Aristada Initio is a medication used to start treatment for schizophrenia in adults, and it works by affecting certain chemicals in the brain to help improve mood and behavior. It is given as a single injection of 675 mg, along with a 30 mg dose of oral aripiprazole, which is taken by mouth. It’s important to know that this injection is only given once and is not meant for repeated use. Patients should avoid this medication if they have had a severe allergic reaction to aripiprazole. Additionally, it should not be used with strong CYP2D6 inhibitors, as this can affect how the medication works in the body.
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Uses

  • Schizophrenia in adults.
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Dosage

One 675 mg injection of ARISTADA INITIO and one 30 mg dose of oral aripiprazole.
ARISTADA INITIO is a single dose and not for repeated use.
Administered by a healthcare professional via intramuscular injection.
For new patients, check tolerability with oral aripiprazole first.
The first ARISTADA injection can be given on the same day or up to 10 days later.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

akathisiainjection site painincreased weightheadacheinsomniaincreased mortality in elderly with dementia-related psychosis

Serious

strokeneuroleptic malignant syndrome
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Warnings

⚠ Important warnings

  • Increased risk of death in elderly patients with dementia-related psychosis.
  • Not approved for treating dementia-related psychosis.
  • Avoid use in known CYP2D6 poor metabolizers.
  • Avoid strong CYP2D6 or CYP3A4 inhibitors and inducers.
  • May cause orthostatic hypotension leading to falls.
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Drug interactions

  • Itraconazoleincreases aripiprazole exposureMonitor
  • Clarithromycinincreases aripiprazole exposureMonitor
  • Quinidineincreases aripiprazole exposureMonitor
  • Fluoxetineincreases aripiprazole exposureMonitor
  • Carbamazepinedecreases aripiprazole exposureCaution
  • Lorazepamincreases sedation and hypotension risk.Monitor

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).