MedDataToolBethkis is a medication used to help manage cystic fibrosis in patients who have a specific type of bacteria called Pseudomonas aeruginosa in their lungs. It works by stopping the bacteria from growing, which helps reduce lung infections. The medication is taken by inhaling the contents of one ampule (300 mg) twice a day for 28 days, followed by 28 days off. It's important to know that Bethkis should not be used if you have a known allergy to aminoglycoside antibiotics. Additionally, it should not be mixed with other medications in the nebulizer, such as dornase alfa.
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Uses
- Cystic fibrosis patients with Pseudomonas aeruginosa.
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Dosage
For patients 6 years and older, use one ampule (300 mg/4 mL) twice daily.
Take doses as close to 12 hours apart as possible, but not less than 6 hours apart.
Use for 28 days on the drug, followed by 28 days off.
Administer by inhalation using a nebulizer for about 15 minutes.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Common side effects include decreased forced expiratory volume and ralesOther common reactions are increased red blood cell sedimentation rate and dysphonia
Serious
Serious side effects may include hearing loss and bronchospasm
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Warnings
⚠ Important warnings
- Not safe for patients under 6 years old.
- Not effective for patients with FEV1 less than 40% or greater than 80%.
- Avoid use in patients colonized with Burkholderia cepacia.
- Do not mix with dornase alfa or other medications in the nebulizer.
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Drug interactions
- Ethacrynic acidincreases risk of toxicityMonitor
- Furosemideincreases risk of toxicityMonitor
- Ureaincreases risk of toxicityMonitor
- Intravenous mannitolincreases risk of toxicityMonitor
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).