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Chlorthalidone Chlorthalidone

Generic: Chlorthalidone

Rx only
Thiazide-like Diuretic✓ FDA-verified
View full FDA label ↗
Chlorthalidone is a medication used to help manage high blood pressure and reduce swelling caused by conditions like heart failure or liver disease. It works by helping your body get rid of extra salt and water, which lowers blood pressure and reduces swelling. You usually take it as a pill once a day in the morning, starting with a dose of 25 mg, which can be increased to a maximum of 100 mg if needed. It's important to be cautious if you have severe kidney problems, as it may worsen your condition. Additionally, be aware that taking chlorthalidone with alcohol or narcotics can increase the risk of low blood pressure.

Uses

  • Hypertension.
  • Edema associated with congestive heart failure.
  • Edema due to hepatic cirrhosis.
  • Edema from corticosteroid therapy.
  • Edema from estrogen therapy.
  • Edema due to nephrotic syndrome.
  • Edema from acute glomerulonephritis.
  • Edema in chronic renal failure.

Dosage

Start with 25 mg once daily for hypertension.
May increase to 50 mg if needed.
For edema, start with 50 to 100 mg daily.
Some may need 150 to 200 mg.
Maintenance doses may be lower than initial doses.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

NauseaVomitingDizzinessHeadacheRashWeaknessHyperglycemiaMuscle crampsRestlessnessOrthostatic hypotension
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Warnings

⚠ Important warnings

  • Use with caution in severe renal disease.
  • May cause azotemia in renal disease.
  • Caution in patients with liver disease.
  • Possible sensitivity reactions in allergic patients.
  • May worsen systemic lupus erythematosus.

Drug interactions

  • Other antihypertensive drugsmay enhance effectsCaution
  • Digitalismay influence serum electrolytesCaution
  • Insulinmay change requirementsCaution
  • Oral hypoglycemic agentsmay need higher dosesCaution

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).