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Climara Pro

Generic: Estradiol And Levonorgestrel

Rx only
Estrogen plus progestin✓ FDA-verified
View full FDA label ↗
Climara Pro is a medication that combines estrogen and progestin to help treat moderate to severe hot flashes due to menopause and to prevent osteoporosis in women who have not had a hysterectomy. It works by balancing hormone levels in the body, which can help alleviate these symptoms. You apply it as a patch to your skin once a week, starting with a dose of 0.045 mg of estrogen and 0.015 mg of progestin, and it should not exceed this dose. It's important to know that this medication should not be used if you have a history of breast cancer or certain blood clots. Additionally, if you are taking other estrogen medications, you should discuss this with your doctor, as it may not be safe to use them together.
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Uses

  • Moderate to severe vasomotor symptoms due to menopause.
  • Prevention of postmenopausal osteoporosis.
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Dosage

Apply 0.045 mg per day/0.015 mg per day once weekly to the lower abdomen.
Start at the lowest effective dose for the shortest duration.
Reevaluate treatment every 3 to 6 months.
Do not apply to or near the breasts.
Rotate application sites weekly.
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Side effects

Common

application site reactionvaginal bleedingbreast painupper respiratory infectionback paindepressionheadacheincreased risk of cardiovascular disorders

Serious

breast cancerendometrial cancer
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Warnings

⚠ Important warnings

  • Increased risk of cardiovascular disorders and probable dementia.
  • Increased risk of breast cancer.
  • Increased risk of endometrial cancer in women with a uterus.
  • Do not use for cardiovascular disease or dementia prevention.
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Drug interactions

  • John's wortmay reduce estrogen effectivenessCaution
  • Erythromycinmay increase estrogen levelsCaution
  • Grapefruit juicemay increase estrogen levelsCaution
  • Phenobarbitalmay reduce estrogen effectivenessCaution
  • Rifampinmay reduce estrogen effectiveness.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).