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Clomipramine

Generic: Clomipramine Hydrochloride

Rx only
Tricyclic antidepressant✓ FDA-verified
View full FDA label ↗
Clomipramine is a medication used to treat obsessive-compulsive disorder (OCD), which involves unwanted thoughts and repetitive behaviors that can cause significant distress. It works by affecting certain chemicals in the brain that help regulate mood and behavior. You typically start with a dose of 25 mg taken daily, which can be gradually increased to a maximum of 250 mg per day for adults, while children and adolescents have a lower maximum based on their weight. It's important to know that clomipramine should not be taken with monoamine oxidase inhibitors (MAOIs), as this can lead to serious side effects. Additionally, if you have a history of heart problems, you should discuss this with your doctor before starting the medication.
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Uses

  • Obsessive-Compulsive Disorder (OCD).
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Dosage

Adults start at 25 mg daily, increase to 100 mg in 2 weeks.
Maximum dose for adults is 250 mg daily.
Children start at 25 mg daily, maximum 3 mg/kg or 100 mg.
Doses should be taken with meals to reduce side effects.
After initial titration, doses may be given once daily at bedtime.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

dry mouthconstipationnauseadizzinessfatigue

Serious

seizuresserotonin syndromesuicidal thoughtsangle-closure glaucoma
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Warnings

⚠ Important warnings

  • Increased risk of suicidal thoughts in young patients.
  • Monitor for worsening depression or unusual behavior changes.
  • Not approved for pediatric patients except for OCD.
  • Do not use with MAO inhibitors.
  • Caution in patients with a history of seizures.
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Drug interactions

  • MAO inhibitorsrisk of serious side effectsCaution
  • Haloperidolincreases clomipramine levelsMonitor
  • Phenobarbitalincreases phenobarbital levelsMonitor
  • SSRIsmay increase clomipramine levelsCaution
  • Anticholinergic drugsrequires careful dosage adjustment.Caution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).