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Clonidine

Generic: Clonidine Hydrochloride

Rx only
Alpha agonist✓ FDA-verified
View full FDA label ↗
Clonidine is a medication used to treat high blood pressure, either on its own or with other blood pressure medications. It works by calming the nervous system, which helps to lower blood pressure. You typically take it as a tablet, starting with 0.1 mg twice a day, and your doctor may increase the dose weekly if needed, with a maximum dose of 2.4 mg per day. It's important not to stop taking clonidine suddenly, as this can cause a rapid increase in blood pressure and other symptoms; always consult your doctor before making any changes. If you are taking a beta-blocker, special care is needed when stopping clonidine, as it should be done gradually after the beta-blocker is discontinued.

Uses

  • Hypertension.

Dosage

Initial dose: 0.1 mg twice daily.
Adjust dose based on blood pressure response.
Elderly patients may need a lower initial dose.
Maintenance doses typically range from 0.2 mg to 0.6 mg daily.
Take larger doses at bedtime to reduce side effects.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

dry mouthdrowsinessdizzinessconstipationsedationfatigue

Serious

headachebradycardiahallucinationssevere allergic reactions
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Warnings

⚠ Important warnings

  • Do not stop taking clonidine suddenly without consulting your doctor.
  • Withdrawal can cause nervousness, headache, and high blood pressure.
  • Gradually reduce the dose over 2 to 4 days when stopping.
  • Be cautious if taking beta-blockers with clonidine.

Drug interactions

  • Alcoholincreases drowsinessMonitor
  • Tricyclic antidepressantsmay reduce clonidine's effectCaution
  • Neurolepticsmay worsen dizziness and fatigueCaution
  • Digitalis, calcium channel blockers, beta-blockersmonitor heart rate closely.Monitor

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).