MedDataToolDesvenlafaxine extended-release tablets are used to treat major depressive disorder in adults. It works by increasing the levels of certain chemicals in the brain that help improve mood. You should take it as a tablet once a day, with a starting and recommended dose of 50 mg, which is also the maximum dose. It's important to know that this medication can increase the risk of suicidal thoughts and behaviors, especially in younger patients. Additionally, you should not take it if you are currently using monoamine oxidase inhibitors (MAOIs), as this can lead to serious side effects.
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Uses
- major depressive disorder.
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Dosage
Take 50 mg once daily, with or without food.
Swallow tablets whole with fluid; do not crush or chew.
For gradual dose reduction, a 25 mg dose is recommended.
Patients with moderate renal impairment should not exceed 50 mg daily.
Patients with severe renal impairment should take 25 mg daily or 50 mg every other day.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nauseadizzinessinsomniadry mouthconstipationvomiting
Serious
suicidal thoughtsserotonin syndromeelevated blood pressureincreased risk of bleeding
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Warnings
⚠ Important warnings
- Increased risk of suicidal thoughts in young adults.
- Not approved for use in children.
- Monitor for worsening depression or suicidal thoughts.
- Do not use with MAOIs or within 14 days of stopping them.
- Risk of serotonin syndrome with other serotonergic drugs.
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Drug interactions
- MAOIsincreased risk of serotonin syndromeMonitor
- Linezolidincreased risk of serotonin syndromeMonitor
- Other serotonergic drugsincreased risk of serotonin syndromeMonitor
- Antiplatelet or anticoagulant drugsincreased risk of bleedingMonitor
- CYP2D6 drugsmay increase toxicity risk.Caution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).