MedDataToolDoxycycline Hyclate is an antibiotic used to treat various infections, including certain types of fevers, respiratory infections, and sexually transmitted infections. It works by stopping bacteria from growing and multiplying in the body. The medication is usually taken by mouth, starting with a dose of 200 mg on the first day (100 mg every 12 hours), followed by a maintenance dose of 100 mg daily. It's important to note that doxycycline can cause permanent tooth discoloration in children under 8 years old, so it should only be used in severe cases when no other options are available. Additionally, you should avoid taking doxycycline with isotretinoin, as this combination can increase the risk of serious side effects.
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Uses
- Rocky Mountain spotted fever.
- Typhus fever.
- Q fever.
- Rickettsialpox.
- Tick fevers caused by Rickettsiae.
- Respiratory tract infections from Mycoplasma pneumoniae.
- Lymphogranuloma venereum from Chlamydia trachomatis.
- Psittacosis from Chlamydophila psittaci.
- Trachoma from Chlamydia trachomatis.
- Inclusion conjunctivitis from Chlamydia trachomatis.
- Uncomplicated urethral, endocervical, or rectal infections from Chlamydia trachomatis.
- Nongonococcal urethritis from Ureaplasma urealyticum.
- Relapsing fever from Borrelia recurrentis.
- Chancroid from Haemophilus ducreyi.
- Plague from Yersinia pestis.
- Tularemia from Francisella tularensis.
- Cholera from Vibrio cholerae.
- Campylobacter fetus infections from Campylobacter fetus.
- Brucellosis from Brucella species.
- Bartonellosis from Bartonella bacilliformis.
- Granuloma inguinale from Klebsiella granulomatis.
- Escherichia coli infections.
- Enterobacter aerogenes infections.
- Shigella species infections.
- Haemophilus influenzae respiratory infections.
- Klebsiella species respiratory and urinary infections.
- Upper respiratory infections from Streptococcus pneumoniae.
- Anthrax from Bacillus anthracis.
- Uncomplicated gonorrhea from Neisseria gonorrhoeae.
- Syphilis from Treponema pallidum.
- Yaws from Treponema pallidum subspecies pertenue.
- Listeriosis from Listeria monocytogenes.
- Vincent's infection from Fusobacterium fusiforme.
- Actinomycosis from Actinomyces israelii.
- Infections from Clostridium species.
- Acute intestinal amebiasis as an adjunct to amebicides.
- Severe acne as adjunctive therapy.
- Prophylaxis of malaria from Plasmodium falciparum.
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Dosage
Adults: 200 mg on the first day, then 100 mg daily.
Pediatric patients under 45 kg: 2.2 mg/kg every 12 hours for severe infections.
Pediatric patients over 45 kg: adult dose.
Take with food or milk if gastric irritation occurs.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
NauseaVomitingDiarrheaGlossitisEsophageal irritationIntracranial hypertension
Serious
Severe skin reactions like Stevens-Johnson syndrome
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Warnings
⚠ Important warnings
- May cause permanent tooth discoloration in children under 8.
- Risk of Clostridium difficile associated diarrhea.
- Severe skin reactions can occur.
- Risk of intracranial hypertension, especially in overweight women.
- Avoid use with isotretinoin.
- May affect anticoagulant therapy.
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Drug interactions
- Anticoagulantsmay require dosage adjustmentCaution
- Penicillinmay interfere with its actionCaution
- Antacidsreduce doxycycline absorptionCaution
- Barbituratesdecrease doxycycline half-lifeCaution
- Carbamazepinedecrease doxycycline half-lifeCaution
- Phenytoindecrease doxycycline half-lifeCaution
Ask about this drug
Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).