MedDataToolDoxycycline Monohydrate is an antibiotic used to treat various infections, including certain types of fevers, respiratory infections, and infections caused by specific bacteria like Chlamydia. It works by stopping bacteria from growing and multiplying. You typically start with a dose of 200 mg on the first day, taken as 100 mg every 12 hours or 50 mg every 6 hours, followed by a maintenance dose of 100 mg each day. It's important to know that this medication can cause permanent tooth discoloration in children under 8 years old, so it should only be used in severe cases when necessary. Additionally, you should avoid taking doxycycline with isotretinoin, as this combination can increase the risk of serious side effects.
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Uses
- Rocky Mountain spotted fever.
- Typhus fever.
- Q fever.
- Rickettsialpox.
- Tick fevers caused by Rickettsiae.
- Respiratory tract infections from Mycoplasma pneumoniae.
- Lymphogranuloma venereum from Chlamydia trachomatis.
- Psittacosis from Chlamydophila psittaci.
- Trachoma from Chlamydia trachomatis.
- Inclusion conjunctivitis from Chlamydia trachomatis.
- Uncomplicated urethral, endocervical or rectal infections from Chlamydia trachomatis.
- Nongonococcal urethritis from Ureaplasma urealyticum.
- Relapsing fever from Borrelia recurrentis.
- Chancroid from Haemophilus ducreyi.
- Plague from Yersinia pestis.
- Tularemia from Francisella tularensis.
- Cholera from Vibrio cholerae.
- Brucellosis from Brucella species.
- Bartonellosis from Bartonella bacilliformis.
- Granuloma inguinale from Klebsiella granulomatis.
- Upper respiratory infections from Streptococcus pneumoniae.
- Anthrax from Bacillus anthracis.
- Uncomplicated gonorrhea from Neisseria gonorrhoeae.
- Syphilis from Treponema pallidum.
- Yaws from Treponema pallidum subspecies pertenue.
- Listeriosis from Listeria monocytogenes.
- Vincent’s infection from Fusobacterium fusiforme.
- Actinomycosis from Actinomyces israelii.
- Infections from Clostridium species.
- Acute intestinal amebiasis as an adjunct to amebicides.
- Severe acne as adjunctive therapy.
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Dosage
- 200 mg on the first day, then 100 mg daily for adults. 2.2 mg/kg every 12 hours for pediatric patients under 45 kg with severe infections. 4.4 mg/kg divided on the first day, then 2.2 mg/kg daily for pediatric patients over 8 years and under 45 kg. 100 mg twice daily for uncomplicated gonococcal infections for adults. 100 mg twice daily for at least 10 days for acute epididymo-orchitis. 100 mg twice daily for at least 10 days for primary and secondary syphilis. 100 mg twice daily for at least 7 days for uncomplicated infections from Chlamydia trachomatis. 100 mg twice daily for at least 10 days for acute epididymo-orchitis from Chlamydia trachomatis. 100 mg twice daily for 60 days for inhalational anthrax in adults. 2.2 mg/kg twice daily for 60 days for children under 45 kg with inhalational anthrax.
- Always follow your doctor's specific instructions for your dose.
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Side effects
Common
NauseaVomitingDiarrheaAnorexiaSkin rashesHeadacheBlurred visionEsophagitisIntracranial hypertension
Serious
Anaphylaxis
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Warnings
⚠ Important warnings
- May cause permanent tooth discoloration in children under 8 years.
- Use only if benefits outweigh risks in severe conditions for children under 8.
- Risk of Clostridium difficile associated diarrhea.
- Monitor for symptoms of intracranial hypertension.
- Avoid use with isotretinoin due to increased risk of intracranial hypertension.
- May affect fetal development if used during pregnancy.
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Drug interactions
- Isotretinoinincreased risk of intracranial hypertensionMonitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).