MedDataToolDuloxetine
Generic: Duloxetine Hydrochloride
SNRIAlso: Duloxetine Delayed-Release✓ FDA-verified
View full FDA label ↗Duloxetine is a medication used to treat conditions like major depressive disorder, generalized anxiety disorder, diabetic nerve pain, fibromyalgia, and chronic musculoskeletal pain. It works by helping to balance certain chemicals in the brain that affect mood and pain. You take it as a delayed-release capsule once a day, starting at a dose of 30 mg to 60 mg, with a maximum dose of 120 mg per day. It's important to know that you should not take this medication if you are currently using certain antidepressants called MAOIs, as this can lead to serious side effects. Additionally, if you have liver disease or severe kidney problems, you should avoid using duloxetine.
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Uses
- Major depressive disorder in adults.
- Generalized anxiety disorder in adults and pediatric patients 7 years and older.
- Diabetic peripheral neuropathic pain in adults.
- Fibromyalgia in adults and pediatric patients 13 years and older.
- Chronic musculoskeletal pain in adults.
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Dosage
Take once daily, with or without food.
Adults with major depressive disorder: 40–60 mg daily.
Adults with generalized anxiety disorder: 60 mg daily.
Adults with diabetic peripheral neuropathic pain: 60 mg daily.
Adults with fibromyalgia: 60 mg daily.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nauseadry mouthsomnolenceconstipationdecreased appetitehyperhidrosis
Serious
suicidal thoughtshepatotoxicityserotonin syndromeincreased risk of bleeding
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Warnings
⚠ Important warnings
- Increased risk of suicidal thoughts in children, adolescents, and young adults.
- Avoid use in patients with severe liver disease.
- Avoid use in patients with severe kidney impairment.
- Monitor for serotonin syndrome with other serotonergic drugs.
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Drug interactions
- Fluvoxamineincreases duloxetine levels significantlyMonitor
- Paroxetineincreases duloxetine levels moderatelyMonitor
- NSAIDsincreased risk of bleedingMonitor
- Warfarinmonitor for altered anticoagulant effects.Monitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).