MedDataToolEntresto
Generic: Sacubitril And Valsartan
Angiotensin II receptor blocker✓ FDA-verified
View full FDA label ↗Entresto is a medication used to help reduce the risk of heart-related deaths and hospitalizations in adults with chronic heart failure, and it can also treat heart failure in children aged one year and older. It works by helping to relax blood vessels and reduce strain on the heart, which can improve blood flow and heart function. Adults typically start with a dose of 49 mg/51 mg taken twice a day, and this can be increased to a maximum of 97 mg/103 mg twice daily as tolerated. It's important to know that Entresto should not be taken with ACE inhibitors, which are another type of heart medication, as this can lead to serious side effects. If you have kidney problems, you may need a lower starting dose, so be sure to discuss your health conditions with your doctor.
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Uses
- Reduce risk of cardiovascular death in adults with chronic heart failure.
- Reduce hospitalization for heart failure in adults.
- Treat symptomatic heart failure in children aged one year and older.
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Dosage
Adults start at 49 mg/51 mg twice daily, increase to 97 mg/103 mg.
Adjust doses every 2 to 4 weeks as tolerated.
For children, refer to specific dosing tables.
Reduce starting dose for patients not on ACE inhibitors or ARBs.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
hypotensioncoughdizziness
Serious
hyperkalemiarenal failureangioedemaimpaired renal functionsevere hypotension
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Warnings
⚠ Important warnings
- Discontinue if pregnancy is detected due to fetal toxicity.
- Contraindicated with ACE inhibitors due to angioedema risk.
- Avoid use with aliskiren in patients with diabetes.
- Monitor renal function if using NSAIDs.
- Use caution in patients with severe renal or hepatic impairment.
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Drug interactions
- Aliskirencontraindicated in diabetesAvoid
- Potassium-sparing diureticsmay increase potassium levelsCaution
- NSAIDsmay worsen renal functionCaution
- Lithiumincreased risk of toxicityMonitor
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).