MedDataToolEstradiol Vaginal Cream is a medication used to treat moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. It works by providing estrogen, which helps restore the health of the vaginal tissue. You typically apply 2 to 4 grams of the cream daily for one or two weeks, then reduce the dose to half for a similar period, and after that, a maintenance dose of 1 gram one to three times a week may be used. It's important to know that this medication should not be used if you have a history of breast cancer or blood clots. Additionally, certain medications like St. John’s Wort can affect how well the cream works, so be sure to discuss all your medications with your healthcare provider.
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Uses
- Moderate to severe vulvar atrophy.
- Moderate to severe vaginal atrophy.
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Dosage
2 to 4 g daily for one or two weeks.
Reduce to half the initial dose for a similar period. 1 g one to three times a week after symptoms improve.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Vaginal burning or irritationAbnormal uterine bleeding or spottingBreast tenderness or painHeadache or migraineIncreased risk of blood clotsIncreased risk of endometrial cancer
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Warnings
⚠ Important warnings
- Increased risk of endometrial cancer with unopposed estrogen.
- Increased risk of stroke and blood clots.
- Not for preventing cardiovascular disease or dementia.
- Monitor for abnormal genital bleeding.
- Use lowest effective dose for shortest time.
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Drug interactions
- John’s Wortmay reduce estrogen effectivenessCaution
- Erythromycinmay increase estrogen levelsCaution
- Grapefruit juicemay increase estrogen levelsCaution
Ask about this product
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).