MedDataToolEstradiol vaginal inserts are a form of estrogen used to treat atrophic vaginitis, which is discomfort in the vaginal area due to menopause. This medication works by replenishing estrogen levels in the body, helping to maintain the health of the vaginal tissues. You will use it by inserting one insert daily for the first two weeks, then switch to one insert twice a week, such as on Tuesdays and Fridays. It's important to note that this medication should not be used if you have a history of breast cancer or certain blood clotting disorders. Additionally, if you have a uterus, your doctor may recommend taking a progestogen along with it to reduce the risk of endometrial cancer.
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Uses
- Atrophic vaginitis due to menopause.
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Dosage
1 insert daily for 2 weeks. 1 insert twice weekly after 2 weeks.
Administer intravaginally using the supplied applicator.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Back painVulvovaginal itchingVulvovaginal fungal infectionDiarrhea
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Warnings
⚠ Important warnings
- Increased risk of endometrial cancer in women with a uterus.
- Increased risk of stroke and deep vein thrombosis.
- Increased risk of probable dementia in women 65 and older.
- Not for preventing cardiovascular disease or dementia.
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Drug interactions
- John’s wortmay reduce estrogen effectivenessCaution
- Phenobarbitalmay reduce estrogen effectivenessCaution
- Carbamazepinemay reduce estrogen effectivenessCaution
- Rifampinmay reduce estrogen effectivenessCaution
- Erythromycinmay increase estrogen levelsCaution
- Grapefruit juicemay increase estrogen levelsCaution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).