MedDataToolFentanyl transdermal is a patch used to manage severe and ongoing pain in patients who are already tolerant to opioids. It works by binding to specific receptors in the brain to reduce the feeling of pain. The patch is applied to the skin and can be worn continuously for up to 72 hours, with a starting dose typically being 25 micrograms per hour, which can be increased based on individual needs, but should not exceed 300 micrograms per hour. It is important to know that this medication is not suitable for those who are not opioid-tolerant, as it can cause serious breathing problems. Additionally, if you are taking medications that affect the liver enzyme CYP3A4, such as certain antifungals or antibiotics, you should be monitored closely, as these can increase the effects of fentanyl and lead to dangerous side effects.
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Uses
- Severe and persistent pain in opioid-tolerant patients.
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Dosage
Prescribed by knowledgeable healthcare providers only.
Start with the lowest effective dose.
Each patch is worn for up to 72 hours.
In patients with mild to moderate liver or kidney issues, start with half the usual dose.
Regularly reassess the need for continued opioid use.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nauseavomitingdizzinessinsomniaconstipationfatiguerespiratory depression
Serious
addictionoverdoseneonatal withdrawal syndrome
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Warnings
⚠ Important warnings
- Risk of addiction, abuse, and misuse.
- Can cause life-threatening respiratory depression.
- Accidental exposure can lead to overdose, especially in children.
- Avoid use with benzodiazepines or other CNS depressants.
- Not for use in patients who are not opioid-tolerant.
- Avoid in severe liver or kidney impairment.
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Drug interactions
- CYP3A4 inhibitorsmay increase fentanyl levelsCaution
- CYP3A4 inducersmay decrease fentanyl effectivenessCaution
- Benzodiazepinesrisk of severe sedation and respiratory depressionCaution
- Serotonergic drugsrisk of serotonin syndromeCaution
- Anticholinergic drugsmay cause urinary retention and constipation.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).