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Fluoxetine

Generic: Fluoxetine Hydrochloride

Rx only
SSRI✓ FDA-verified
View full FDA label ↗
Fluoxetine is a medication used to treat conditions like major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, and panic disorder. It works by increasing the levels of serotonin, a chemical in the brain that helps improve mood. You typically take it in capsule form, starting with a dose of 20 mg once a day, which can be increased to a maximum of 80 mg per day if needed. A key warning is that it should not be taken with certain other medications, specifically monoamine oxidase inhibitors (MAOIs), as this can lead to serious side effects. Additionally, if you are pregnant, your doctor will carefully consider the risks and benefits before prescribing it.

Uses

  • Major Depressive Disorder.
  • Obsessive Compulsive Disorder (OCD).
  • Bulimia Nervosa.
  • Panic Disorder.
  • Bipolar I Disorder (in combination with olanzapine).

Dosage

Adults: 20 mg/day for Major Depressive Disorder, OCD; 60 mg/day for Bulimia Nervosa; 10 mg/day for Panic Disorder.
Pediatrics: 10 to 20 mg/day for Major Depressive Disorder and OCD.
Lower doses for elderly or those with liver issues.
Take in the morning, with or without food.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

abnormal dreamsanxietydiarrheadry mouthinsomnianausea

Serious

suicidal thoughtsserotonin syndromeallergic reactionsseizures
🛑

Warnings

⚠ Important warnings

  • Increased risk of suicidal thoughts in young adults.
  • Not approved for children under 7 years.
  • Monitor for worsening symptoms.
  • Avoid use with thioridazine or pimozide due to QT prolongation.
  • Use caution in patients with liver impairment.

Drug interactions

  • MAOIsrisk of serious side effectsCaution
  • Tricyclic Antidepressantsmay increase TCA levelsCaution
  • Benzodiazepinesmay increase sedationCaution
  • Antipsychoticsmay elevate blood levelsCaution
  • Warfarinmay increase bleeding risk.Caution

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).