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Hydralazine

Generic: Hydralazine Hydrochloride

Rx only
Vasodilator✓ FDA-verified
View full FDA label ↗
Hydralazine is a medication used to treat high blood pressure, either on its own or with other treatments. It helps lower blood pressure by relaxing the blood vessels, making it easier for blood to flow. You typically start with 10 mg taken four times a day for the first few days, then increase to 25 mg four times daily for the rest of the first week, and finally up to 50 mg four times daily as needed, but the lowest effective dose is preferred. It's important to know that hydralazine can cause serious side effects that mimic lupus, so if you experience unusual symptoms, you should talk to your doctor right away. Additionally, if you have coronary artery disease, you should not take this medication.

Uses

  • Essential hypertension.

Dosage

Start with 10 mg four times daily for 2 to 4 days.
Increase to 25 mg four times daily for the first week.
For the second week and beyond, increase to 50 mg four times daily.
Adjust dosage to the lowest effective levels for maintenance.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

headachenauseavomitingdiarrheapalpitationstachycardiaangina pectorisanorexiasymptoms resembling systemic lupus erythematosusblood disorders like leukopenia and purpura

Serious

severe allergic reactions like rash and fever
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Warnings

⚠ Important warnings

  • May cause symptoms similar to lupus; discontinue if this occurs.
  • Long-term steroid treatment may be needed for lupus-like symptoms.
  • Monitor for toxic reactions with high doses.
  • Adjust doses carefully when combining with other medications.

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).