MedDataToolInspra is a medication used to help improve survival in adults with heart failure after a heart attack and to lower high blood pressure. It works by blocking a hormone that can cause the body to retain salt and water, which helps to relax blood vessels and reduce blood pressure. You typically take it as a pill, starting with 25 mg once daily for heart failure or 50 mg once daily for high blood pressure, and it can be increased to a maximum of 50 mg once daily for heart failure or 50 mg twice daily for blood pressure if needed. It's important to know that you should not take it if your potassium levels are too high, as this can lead to serious health issues. Additionally, be cautious if you are taking strong CYP3A inhibitors like ketoconazole, as they can increase the levels of Inspra in your body.
✦
Uses
- Heart failure with reduced ejection fraction after a heart attack.
- High blood pressure in adults.
◷
Dosage
Heart failure: Start at 25 mg once daily, increase to 50 mg once daily as tolerated.
Hypertension: 50 mg once daily, may increase to 50 mg twice daily if needed.
Monitor potassium levels before starting and during treatment.
Always follow your doctor's specific instructions for your dose.
⚠
Side effects
Common
High potassium levelsincreased creatinine
Serious
Angioedemarashdizzinessheadache
🛑
Warnings
⚠ Important warnings
- Risk of high potassium levels, especially with kidney issues.
- Monitor potassium and kidney function closely.
- Not recommended with strong CYP3A inhibitors.
⇄
Drug interactions
- Verapamilmay increase eplerenone levelsCaution
- Erythromycinmay increase eplerenone levelsCaution
- Saquinavirmay increase eplerenone levelsCaution
- Fluconazolemay increase eplerenone levelsCaution
- ACE inhibitorsincreased risk of high potassium.Monitor
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).