MedDataToolMedDataTool

Invega Sustenna

Generic: Paliperidone Palmitate

Rx only
Atypical antipsychotic✓ FDA-verified
View full FDA label ↗
Invega Sustenna is a medication used to treat schizophrenia and schizoaffective disorder in adults. It works by affecting certain chemicals in the brain to help improve mood and thinking. The medication is given as an injection by a healthcare professional, starting with a dose of 234 mg on the first day, followed by 156 mg a week later, and then a monthly maintenance dose that can range from 39 mg to 234 mg. It's important to know that Invega Sustenna is not recommended for individuals with severe kidney problems. Additionally, if you are taking strong medications like carbamazepine, which can affect how Invega Sustenna works, you should discuss this with your doctor.
✦

Uses

  • Schizophrenia in adults.
  • Schizoaffective disorder in adults.
◷

Dosage

Administered by a healthcare professional only.
Initial dose for schizophrenia: 234 mg on Day 1, 156 mg on Day 8.
Monthly maintenance dose: 39–234 mg, typically 117 mg.
Initial dose for schizoaffective disorder: 234 mg on Day 1, 156 mg on Day 8.
Monthly maintenance dose: 78–234 mg, adjusted based on response.
Always follow your doctor's specific instructions for your dose.
⚠

Side effects

Common

injection site reactionssomnolencedizzinessakathisiaextrapyramidal disorderincreased mortality in elderly with dementia-related psychosis

Serious

strokeneuroleptic malignant syndrome
🛑

Warnings

⚠ Important warnings

  • Increased risk of death in elderly patients with dementia-related psychosis.
  • Not approved for dementia-related psychosis.
  • Caution in patients with renal impairment.
  • Avoid strong CYP3A4/P-gp inducers.
  • Monitor for orthostatic hypotension.
⇄

Drug interactions

  • Centrally Acting Drugsmay increase CNS effectsCaution
  • Alcoholmay increase CNS effectsCaution
  • Carbamazepinemay decrease paliperidone levelsCaution
  • Rifampinmay decrease paliperidone levelsCaution
  • John's Wortmay decrease paliperidone levels.Caution

Ask about this drug

Answers pulled from the FDA label only.

AI
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).