MedDataToolIsosorbide dinitrate is a medication used to help prevent angina, which is chest pain caused by reduced blood flow to the heart. It works by relaxing blood vessels, making it easier for blood to flow and reducing the heart's workload. You typically take it in tablet form, starting with a dose of 5 mg to 20 mg two or three times a day, and the maximum dose can go up to 40 mg, but you should have a break of at least 14 hours each day to avoid tolerance. It's important to know that this medication should not be taken with certain erectile dysfunction drugs, like sildenafil, as this can lead to dangerously low blood pressure. If you have any allergies to isosorbide dinitrate or its ingredients, you should not use it.
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Uses
- Prevention of angina pectoris due to coronary artery disease.
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Dosage
Starting dose is 5 mg to 20 mg, two or three times daily.
For maintenance, 10 mg to 40 mg, two or three times daily.
A daily dose-free interval of at least 14 hours is recommended.
The optimal interval may vary by patient and regimen.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Headaches may occur with each doseespecially at higher dosesHypotension may occur but is infrequent
Serious
Common side effects include severe headache and lightheadednessSerious side effects like syncope and rebound hypertension are uncommonMethemoglobinemia is extremely rare
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Warnings
⚠ Important warnings
- Using isosorbide dinitrate with sildenafil can cause severe low blood pressure.
- Careful monitoring is needed if used during heart attacks or heart failure.
- Not recommended for rapid relief of angina.
- Concomitant use with phosphodiesterase inhibitors is contraindicated.
- Concomitant use with riociguat is contraindicated.
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Drug interactions
- Sildenafilmay cause severe low blood pressureCaution
- Alcoholmay increase blood pressure-lowering effects.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).