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Janumet Xr

Generic: Sitagliptin And Metformin Hydrochloride

Rx only
DPP-4 inhibitor✓ FDA-verified
View full FDA label ↗
Janumet XR is a medication used to help adults with type 2 diabetes manage their blood sugar levels, alongside a healthy diet and exercise. It combines two active ingredients that work together: one helps increase insulin production in response to meals, while the other reduces the amount of sugar produced by the liver. You take it as a tablet once a day with a meal, starting with a dose of 100 mg of sitagliptin and 1000 mg of metformin, and the maximum daily dose is 100 mg of sitagliptin and 2000 mg of metformin. It's important to know that Janumet XR should not be used if you have severe kidney problems. Additionally, if you are taking certain medications like insulin, you may need to be cautious as they can increase the risk of low blood sugar.
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Uses

  • Type 2 diabetes mellitus.
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Dosage

Take JANUMET XR orally once daily with a meal.
Patients taking two tablets should take them together.
Maximum daily dose is 100 mg sitagliptin and 2000 mg metformin.
Starting dose for those not on metformin is 100 mg sitagliptin and 1000 mg metformin.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

diarrheaupper respiratory tract infectionheadachelactic acidosis

Serious

pancreatitisheart failureacute renal failure
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Warnings

⚠ Important warnings

  • Not for type 1 diabetes.
  • Not studied in patients with pancreatitis history.
  • Discontinue if kidney function worsens.
  • Monitor renal function before starting and periodically.
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Drug interactions

  • Alcoholincreases risk of lactic acidosisMonitor
  • Topiramatemay increase risk of lactic acidosisCaution
  • Cimetidinemay increase metformin levelsCaution
  • Insulinmay increase risk of low blood sugar.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).