MedDataToolLamotrigine Extended-Release Tablets are used to help control certain types of seizures, including primary generalized tonic-clonic seizures and partial-onset seizures, in patients aged 13 and older. It works by stabilizing the electrical activity in the brain, which helps prevent seizures. The medication is taken once daily as a whole tablet, with a starting dose of 25 mg to 50 mg, and can be increased to a maximum of 600 mg per day, depending on other medications you may be taking. A key warning is that it can cause serious skin rashes, so it's important to follow dosing instructions carefully. Additionally, if you are taking valproate, this can significantly increase the levels of lamotrigine in your body, so your doctor may need to adjust your dose.
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Uses
- Primary generalized tonic-clonic seizures.
- Partial-onset seizures.
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Dosage
Take once daily, with or without food.
Swallow tablets whole; do not chew, crush, or divide.
Dosing varies based on other medications.
No established dosing for patients under 13 years.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
DizzinessRashNauseaHeadache
Serious
Serious skin rashesSuicidal thoughts
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Warnings
⚠ Important warnings
- Can cause serious skin rashes requiring hospitalization.
- Not approved for patients younger than 13 years.
- Risk of severe rash may increase with valproate.
- Follow dosing recommendations closely to avoid risks.
- Monitor for rash; discontinue if it occurs.
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Drug interactions
- Valproateincreases lamotrigine levelsMonitor
- Carbamazepinedecreases lamotrigine levelsCaution
- Phenytoindecreases lamotrigine levelsCaution
- Phenobarbitaldecreases lamotrigine levelsCaution
- Rifampindecreases lamotrigine levelsCaution
- Estrogen-containing contraceptivesdecreases lamotrigine levels.Caution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).