Nortriptyline
Generic: Nortriptyline Hydrochloride
Tricyclic antidepressant✓ FDA-verified
View full FDA label ↗Nortriptyline is a medication used to help relieve symptoms of depression. It works by affecting certain chemicals in the brain that help improve mood. You take it in capsule form, usually starting with a dose of 25 mg taken three or four times a day, and it can be increased as needed, but should not exceed 150 mg per day. It's important to know that nortriptyline should not be taken if you have recently used a type of medication called monoamine oxidase inhibitors (MAOIs), as this can lead to serious side effects. Additionally, be cautious if you're taking other serotonergic drugs, as combining them with nortriptyline can increase the risk of a serious condition called serotonin syndrome.
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Uses
- Depression symptoms relief.
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Dosage
Adults: 25 mg three or four times daily.
Elderly and adolescents: 30 to 50 mg daily in divided doses.
Start with a low dose and increase gradually.
Monitor closely for side effects.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Dry mouthblurred visionconstipationdrowsinessdizzinessHeart issues
Serious
seizureshallucinationsallergic reactionsjaundice
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Warnings
⚠ Important warnings
- Increased risk of suicidal thoughts in young adults.
- Not recommended for children.
- Monitor for worsening depression or unusual behavior.
- Use cautiously in patients with heart disease or seizures.
- Avoid use with MAOIs like linezolid or methylene blue.
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Drug interactions
- Linezolidincreased risk of serotonin syndromeMonitor
- Methylene blueincreased risk of serotonin syndromeMonitor
- Quinidinemay increase nortriptyline levelsCaution
- Alcoholmay increase risk of side effects.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
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