MedDataToolNoxafil is an antifungal medication used to treat serious fungal infections like invasive aspergillosis and oropharyngeal candidiasis, especially in patients with weakened immune systems. It works by blocking the growth of fungi in the body, making it harder for them to survive. You can take Noxafil as an injection, delayed-release tablets, or an oral suspension, with the starting dose typically being 300 mg on the first day, followed by a maintenance dose of 300 mg daily, but the exact dose may vary based on your condition and weight. It's important to know that Noxafil should not be taken with sirolimus, as this combination can lead to serious side effects. Additionally, if you have a known allergy to posaconazole or other similar antifungal medications, you should not use Noxafil.
✦
Uses
- treatment of invasive aspergillosis. prophylaxis of invasive Aspergillus infections. prophylaxis of Candida infections. treatment of oropharyngeal candidiasis.
◷
Dosage
300 mg injection twice daily on the first day, then 300 mg once daily. 300 mg delayed-release tablets twice daily on the first day, then 300 mg once daily. 200 mg oral suspension three times a day.
Pediatric doses vary based on weight and age.
Always follow your doctor's specific instructions for your dose.
⚠
Side effects
Common
diarrheanauseafevervomitingheadachecoughinghypokalemiaarrhythmias
Serious
electrolyte disturbanceshepatic toxicity
🛑
Warnings
⚠ Important warnings
- Contraindicated with pimozide and ergot alkaloids.
- Monitor for breakthrough fungal infections with certain drugs.
- Use cautiously in patients with renal impairment.
⇄
Drug interactions
- Efavirenzmay decrease posaconazole effectivenessCaution
- Rifabutinmay increase rifabutin levelsCaution
- Phenytoinmay increase phenytoin levelsCaution
- Cimetidinemay decrease posaconazole levelsCaution
- Esomeprazolemay decrease posaconazole levelsCaution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).