MedDataToolPerphenazine is a medication used to treat schizophrenia and to help control severe nausea and vomiting in adults. It works by affecting certain chemicals in the brain to help improve mood and reduce symptoms of these conditions. You typically take it in tablet form, starting with a dose of 4 to 8 mg three times a day for schizophrenia, with a maximum dose of 64 mg daily for hospitalized patients. It's important to know that this medication is not approved for treating dementia-related psychosis in elderly patients, as it can increase the risk of death in that population. Additionally, be cautious if you're taking other central nervous system depressants, like alcohol or narcotics, as this can lead to serious side effects.
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Uses
- Schizophrenia.
- Severe nausea and vomiting in adults.
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Dosage
4 mg to 8 mg three times daily for nonhospitalized schizophrenia patients. 8 mg to 16 mg two to four times daily for hospitalized schizophrenia patients. 8 mg to 16 mg daily for severe nausea and vomiting in adults.
Dosage should be adjusted based on response and severity of condition.
Lower doses are recommended for elderly patients.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
DrowsinessDry mouthNauseaVomitingExtrapyramidal symptoms like muscle spasmsTardive dyskinesia with long-term use
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Warnings
⚠ Important warnings
- Increased risk of death in elderly patients with dementia-related psychosis.
- Risk of tardive dyskinesia, especially in elderly patients.
- Neuroleptic Malignant Syndrome (NMS) may occur.
- Use caution in patients with convulsive disorders.
- Not recommended for children under 12 years old.
- Safe use during pregnancy and lactation not established.
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Drug interactions
- Tricyclic antidepressantsmay increase side effectsCaution
- Fluoxetinemay increase plasma concentrationsCaution
- Sertralinemay increase plasma concentrationsCaution
- Paroxetinemay increase plasma concentrationsCaution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).