MedDataToolPimozide is a medication used to help control motor and vocal tics in people with Tourette’s Disorder who haven't found relief from other treatments. It works by blocking certain brain signals that are involved in these tics. The medication is taken as a tablet, usually starting at a dose of 1 to 2 mg per day for adults, which can be increased every other day, but should not exceed 10 mg per day. One important warning is that it can cause serious movement disorders, so it should be used carefully and monitored by a doctor. Additionally, pimozide should not be taken with certain antidepressants like Celexa or Lexapro, as this can lead to dangerous side effects.
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Uses
- Tourette’s Disorder.
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Dosage
Adults typically start with 1 to 2 mg daily.
Doses may be increased every other day.
Most adults are maintained at less than 10 mg daily.
Children under 12 start at 0.05 mg/kg at bedtime.
Children's doses may increase to a maximum of 10 mg daily.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Common side effects include drowsinessdry mouthand headacheOther side effects can include muscle crampsvisual disturbancesand constipationSome patients may experience increased nervousness or abnormal behaviorWithdrawal symptoms may occur if the medication is stopped abruptly
Serious
Serious side effects may include tardive dyskinesia and neuroleptic malignant syndrome
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Warnings
⚠ Important warnings
- Risk of tardive dyskinesia, especially in elderly patients.
- Neuroleptic malignant syndrome can be life-threatening.
- Pimozide may prolong the QT interval, leading to serious heart issues.
- Avoid using with drugs that also prolong the QT interval.
- Gradual withdrawal is recommended to avoid withdrawal symptoms.
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Drug interactions
- Citalopramincreases risk of QT prolongationMonitor
- Paroxetineincreases pimozide levels significantlyMonitor
- Azole antifungalsmay inhibit pimozide metabolismCaution
- Macrolide antibioticsmay cause ventricular arrhythmiasCaution
- Grapefruit juicemay inhibit pimozide metabolism.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).