MedDataToolPrometrium is a medication that contains progesterone and is used to help prevent a condition called endometrial hyperplasia in postmenopausal women who are also taking estrogen. It works by balancing hormones in the body. The medication is taken as a capsule, usually at bedtime, with a starting dose of 200 mg for 12 days each month for endometrial hyperplasia, or 400 mg for 10 days for secondary amenorrhea. It's important to know that Prometrium should not be used if you have a history of breast cancer or blood clots. Additionally, if you are taking ketoconazole, it may increase the effects of Prometrium, so be sure to discuss this with your doctor.
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Uses
- Prevention of endometrial hyperplasia.
- Secondary amenorrhea.
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Dosage
- 200 mg at bedtime for 12 days per 28-day cycle for endometrial hyperplasia.. 400 mg at bedtime for 10 days for secondary amenorrhea.
- Take with a glass of water if you have trouble swallowing.
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Side effects
Common
headachebreast tendernessjoint paindizzinessabdominal bloatingblood clots
Serious
strokeheart attackbreast cancer
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Warnings
⚠ Important warnings
- Not for women with active blood clots or a history of blood clots.
- Discontinue if blood clots, stroke, or heart attack occurs.
- Not recommended before surgery with high blood clot risk.
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Drug interactions
- Ketoconazolemay increase progesterone levels.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).