MedDataToolPropofol injectable emulsion is a medication used for inducing and maintaining general anesthesia, as well as for sedation in adults during certain medical procedures. It works by enhancing the effects of a natural calming substance in the brain, helping to relax patients quickly. This medication is given through an intravenous (IV) line, with starting doses typically ranging from 2 mg/kg to 2.5 mg/kg for adults, and it can be adjusted based on the patient's response, but should not exceed 4 mg/kg/hour in the ICU. It is important to note that propofol should not be used in patients who have a known allergy to it or its ingredients, especially if they are allergic to eggs or soy. Additionally, using propofol with other sedatives or opioids can increase the risk of breathing problems and should be done with caution.
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Uses
- Induction of general anesthesia for patients 3 years and older.
- Maintenance of general anesthesia for patients 2 months and older.
- Monitored anesthesia care (MAC) sedation in adults.
- Sedation for adults with regional anesthesia.
- ICU sedation for intubated, mechanically ventilated adults.
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Dosage
Adults under 65: 2 mg/kg to 2.5 mg/kg for induction.
Elderly or debilitated: 1 mg/kg to 1.5 mg/kg for induction.
Pediatric patients 3 to 16 years: 2.5 mg/kg to 3.5 mg/kg for induction.
ICU sedation: Start at 5 mcg/kg/min, adjust as needed.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
bradycardiahypotensionapnearashburning at injection sitehypersensitivity reactions
Serious
Propofol Infusion Syndromesevere hypotension
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Warnings
⚠ Important warnings
- Not recommended for patients under 3 years for induction.
- Not recommended for patients under 2 months for maintenance.
- Use caution in elderly or debilitated patients.
- Monitor for respiratory depression and hypotension.
- Avoid rapid bolus administration in certain patients.
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Drug interactions
- Opioidsmay increase sedation and hypotensionCaution
- Valproatemay increase blood levels of propofolCaution
- Sedativesmay enhance sedative effects of propofolCaution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).