MedDataToolPropylthiouracil is a medication used to treat conditions like Graves’ disease and hyperthyroidism when other treatments are not suitable. It works by reducing the production of thyroid hormones in the body. You take it by mouth, usually in three doses throughout the day, starting with 300 mg daily, which can be increased to a maximum of 900 mg if needed. A key warning is that it can cause serious liver damage, so you should watch for symptoms like loss of appetite or pain in the upper right side of your abdomen and report them to your doctor right away. This medication is generally not recommended for children unless absolutely necessary, especially since it can cause liver problems.
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Uses
- Graves' disease with hyperthyroidism.
- Toxic multinodular goiter.
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Dosage
Adults: Start with 300 mg daily, usually in 3 doses every 8 hours.
For severe cases, doses may be increased to 400 mg or more.
Pediatric use is rare; typically starts at 50 mg daily for ages 6 and older.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Skin rashnauseavomitingheadachedrowsiness
Serious
Liver injuryagranulocytosisvasculitissevere allergic reactions
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Warnings
⚠ Important warnings
- Severe liver injury and failure can occur.
- Not recommended for children unless other treatments are unsuitable.
- Monitor liver function closely, especially in the first six months.
- Can cause hypothyroidism; regular monitoring is needed.
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).