MedDataToolQuetiapine Fumarate ER is a medication used to treat conditions like schizophrenia, bipolar disorder, and major depressive disorder. It works by affecting certain chemicals in the brain that help improve mood and thoughts. You take it as an extended-release tablet, usually once a day in the evening, starting with a dose of 300 mg for adults, which can be increased up to a maximum of 800 mg. It's important to know that this medication can increase the risk of serious side effects in elderly patients with dementia-related psychosis. Additionally, if you're taking strong medications that affect liver enzymes, like ketoconazole, your doctor may need to adjust your quetiapine dose significantly.
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Uses
- Schizophrenia in adults and adolescents (13 to 17 years).
- Acute manic or mixed episodes of bipolar I disorder in adults and children (10 to 17 years).
- Depressive episodes associated with bipolar disorder in adults.
- Maintenance treatment of bipolar I disorder in adults.
- Adjunctive treatment of major depressive disorder in adults.
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Dosage
Adults: Start at 300 mg for schizophrenia, adjust as needed.
Adolescents: Start at 50 mg for schizophrenia, increase daily.
Elderly: Start at 50 mg, adjust slowly.
Hepatic impairment: Start at 50 mg, adjust as needed.
Take once daily in the evening, preferably without food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Somnolencedry mouthdizzinessconstipationweight gainIncreased mortality in elderly with dementia-related psychosis
Serious
suicidal thoughtsstrokeneuroleptic malignant syndromemetabolic changestardive dyskinesia
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Warnings
⚠ Important warnings
- Increased risk of death in elderly patients with dementia-related psychosis.
- Risk of suicidal thoughts and behaviors in children and young adults.
- Not approved for dementia-related psychosis treatment.
- Use caution in elderly and patients with liver or kidney issues.
- Monitor for worsening symptoms when starting treatment.
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Drug interactions
- Ketoconazoleincreases quetiapine levels significantlyMonitor
- Phenytoindecreases quetiapine levels significantlyCaution
- Alcoholenhances cognitive and motor effectsCaution
- Anticholinergic drugsincreases risk of gastrointestinal issues.Monitor
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).