MedDataToolRanolazine is a medication used to treat chronic angina, which is chest pain caused by reduced blood flow to the heart. It works by helping to improve blood flow and reduce the heart's workload without significantly affecting heart rate or blood pressure. You take it as an extended-release tablet, starting with 500 mg twice a day, and it can be increased to a maximum of 1000 mg twice a day based on your symptoms. It's important to know that ranolazine should not be taken with strong CYP3A inhibitors like ketoconazole, as this can increase the levels of the medication in your body and lead to side effects. Always talk to your doctor about any other medications you are taking to avoid potential interactions.
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Uses
- chronic angina.
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Dosage
Start with 500 mg twice daily.
Can increase to 1000 mg twice daily as needed.
Take with or without meals.
Swallow whole; do not crush, break, or chew.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Common side effects include dizzinessheadacheconstipationand nausea
Serious
Serious side effects may include abnormal coordinationhallucinationsand renal failure
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Warnings
⚠ Important warnings
- Do not use with strong CYP3A inhibitors like ketoconazole.
- Limit dose to 500 mg twice daily with moderate CYP3A inhibitors.
- Monitor closely if using with P-gp inhibitors like cyclosporine.
- Use caution in patients with severe renal impairment.
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Drug interactions
- Diltiazemlimit ranolazine to 500 mg twice dailyCaution
- Verapamillimit ranolazine to 500 mg twice dailyCaution
- Erythromycinlimit ranolazine to 500 mg twice dailyCaution
- Simvastatinlimit to 20 mg when used with ranolazineCaution
- Metformindo not exceed 1700 mg daily with ranolazine.Avoid
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).