MedDataToolRexulti is a medication used to help treat major depressive disorder in adults when combined with antidepressants, schizophrenia in adults and teens aged 13 and older, and agitation related to Alzheimer's disease. It works by affecting certain chemicals in the brain that help improve mood and thinking. You take it as a pill once a day, starting with a dose of 0.5 mg or 1 mg, and the maximum dose is 3 mg for depression or agitation, and 4 mg for schizophrenia. It's important to know that Rexulti should not be taken if you have a known allergy to it or its ingredients. Additionally, if you are taking strong CYP2D6 inhibitors, like paroxetine or fluoxetine, your doctor may need to adjust your dose.
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Uses
- Major depressive disorder in adults.
- Schizophrenia in adults and patients ages 13 and older.
- Agitation associated with dementia due to Alzheimer's disease.
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Dosage
Adults with major depressive disorder: starting at 0.5 mg or 1 mg, up to 3 mg once daily.
Adults with schizophrenia: starting at 1 mg, up to 4 mg once daily.
Pediatric patients (13-17 years) with schizophrenia: starting at 0.5 mg, up to 4 mg once daily.
Agitation due to Alzheimer's: starting at 0.5 mg, up to 3 mg once daily.
Take REXULTI orally once daily, with or without food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
weight gainsleepinessrestlessnessheadachedizziness
Serious
increased risk of death in elderly with dementiasuicidal thoughtsstrokeneuroleptic malignant syndrome
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Warnings
⚠ Important warnings
- Increased mortality in elderly patients with dementia-related psychosis.
- Risk of suicidal thoughts and behaviors in young adults.
- Not approved for dementia-related psychosis without agitation.
- Monitor for worsening symptoms in patients taking antidepressants.
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Drug interactions
- Strong CYP3A4 inhibitorsreduce REXULTI dosageCaution
- Strong CYP2D6 inhibitorsmay not need dosage adjustmentCaution
- Both CYP3A4 and CYP2D6 inhibitorsreduce REXULTI dosageCaution
- Strong CYP3A4 inducersincrease REXULTI dosage.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).