MedDataToolSaphris is a medication used to treat schizophrenia in adults and bipolar I disorder in both adults and children aged 10 to 17. It works by affecting certain chemicals in the brain that help manage mood and thought processes. The medication comes in the form of sublingual tablets, which means you place it under your tongue to let it dissolve; the usual starting dose is 5 mg taken twice daily, with a maximum dose of 10 mg twice daily. It's important to know that Saphris should not be taken if you have severe liver problems or a history of severe allergic reactions to it. Additionally, taking Saphris with paroxetine, an antidepressant, can significantly increase the levels of paroxetine in your body, so be sure to discuss any other medications you are taking with your doctor.
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Uses
- Schizophrenia in adults.
- Bipolar I disorder in adults.
- Bipolar I disorder in pediatric patients aged 10 to 17.
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Dosage
- 5 mg sublingually twice daily for schizophrenia acute treatment in adults. 5-10 mg sublingually twice daily for schizophrenia maintenance treatment in adults. 5-10 mg sublingually twice daily for bipolar mania in adults. 2.5-10 mg sublingually twice daily for bipolar mania in pediatric patients. 5 mg sublingually twice daily as adjunctive therapy with lithium or valproate in adults.
- Always follow your doctor's specific instructions for your dose.
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Side effects
Common
akathisiaoral hypoesthesiasomnolencedizzinessnauseaneuroleptic malignant syndrome
Serious
tardive dyskinesiaseizuresfalls
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Warnings
⚠ Important warnings
- Increased mortality in elderly patients with dementia-related psychosis.
- Not approved for dementia-related psychosis treatment.
- Risk of hypotension with antihypertensive drugs.
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Drug interactions
- Antihypertensive Drugsmay enhance effects and cause low blood pressureCaution
- Paroxetineincrease in paroxetine exposure, reduce dose by halfCaution
- Strong CYP1A2 Inhibitorsmay increase asenapine exposureCaution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).