MedDataToolSpironolactone is a medication used to treat heart failure, high blood pressure, and certain types of swelling caused by liver or kidney problems. It works by helping your body get rid of excess salt and water while keeping potassium, which can help lower blood pressure and reduce swelling. You typically start with a dose of 25 mg to 100 mg taken once daily, depending on your condition, and the maximum dose can go up to 400 mg for specific situations. It's important to know that spironolactone can increase potassium levels in your blood, so you should avoid using it with potassium supplements or salt substitutes that contain potassium. If you have kidney problems, this medication may not be suitable for you, so be sure to discuss your health history with your doctor.
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Uses
- Heart failure (NYHA Class III-IV).
- Hypertension.
- Edema in cirrhosis.
- Nephrotic syndrome.
- Primary hyperaldosteronism.
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Dosage
Heart Failure: Start at 25 mg once daily.
Hypertension: Start at 25 to 100 mg daily.
Edema: Start at 100 mg daily in a hospital.
Primary Hyperaldosteronism: Start at 100 to 400 mg daily.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Gynecomastialeg crampsdizziness
Serious
Hyperkalemiarenal dysfunctiongastric bleeding
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Warnings
⚠ Important warnings
- Risk of hyperkalemia (high potassium levels).
- May cause low blood pressure and worsening kidney function.
- Monitor for electrolyte and metabolic abnormalities.
- Use caution in patients with liver impairment.
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Drug interactions
- Potassium supplementsrisk of severe hyperkalemiaCaution
- Lithiumincreased risk of lithium toxicityMonitor
- NSAIDsmay reduce spironolactone's effectivenessCaution
- Acetylsalicylic Acidmay reduce spironolactone's efficacy.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).