MedDataToolSporanox is a medication used to treat certain fungal infections, including blastomycosis, histoplasmosis, aspergillosis, and nail infections caused by dermatophytes. It works by stopping the growth of fungi by interfering with their cell membranes. You take it in capsule form, usually starting with 200 mg once a day, and the dose can be increased to a maximum of 400 mg daily if needed. A key warning is that it should not be used in patients with congestive heart failure, as it can worsen this condition. Additionally, you should avoid taking it with certain medications like methadone, as this can lead to serious side effects.
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Uses
- Blastomycosis.
- Pulmonary and extrapulmonary Histoplasmosis.
- Aspergillosis.
- Onychomycosis of the toenail.
- Onychomycosis of the fingernail.
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Dosage
200 mg once daily for Blastomycosis and Histoplasmosis. 200 mg once daily for 12 weeks for toenail onychomycosis. 200 mg twice daily for 1 week for fingernail onychomycosis, followed by 3 weeks off.
Take with a full meal.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
NauseaVomitingDiarrheaHeadache
Serious
Serious liver problems including liver failureHeart failure
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Warnings
⚠ Important warnings
- Do not use in patients with heart failure.
- Risk of serious liver toxicity.
- Monitor for signs of heart failure.
- Avoid use with certain medications like methadone and pimozide.
- Use caution in patients with liver or kidney issues.
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Drug interactions
- Methadonecontraindicated during and after treatmentAvoid
- Disopyramidecontraindicated during and after treatmentAvoid
- Dofetilidecontraindicated during and after treatmentAvoid
- Quinidinecontraindicated during and after treatmentAvoid
- Felodipinecontraindicated during and after treatmentAvoid
- Nisoldipinecontraindicated during and after treatmentAvoid
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).