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Sterile Diluent For Treprostinil

Generic: Treprostinil

Rx only
Prostaglandin✓ FDA-verified
View full FDA label ↗
Treprostinil is a medication used to treat pulmonary arterial hypertension (PAH), a condition that affects blood flow in the lungs and can cause symptoms like shortness of breath during exercise. It works by relaxing blood vessels, which helps improve blood flow and reduces the strain on the heart. The medication is given as a continuous infusion either under the skin or through an intravenous line, starting at a dose of 1.25 nanograms per kilogram per minute, which can be increased based on how well you respond, with a maximum dose that can go much higher. It's important to avoid stopping the medication suddenly, as this can lead to serious problems. Additionally, if you're taking a medication called gemfibrozil, which is used to lower cholesterol, it can significantly increase the levels of treprostinil in your body, so your doctor may need to adjust your treatment.
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Uses

  • Pulmonary arterial hypertension (PAH).
  • Symptoms associated with exercise.
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Dosage

Start at 1.25 ng/kg/min for new patients.
Increase based on response, up to 2.5 ng/kg/min per week after 4 weeks.
For mild to moderate liver issues, start at 0.625 ng/kg/min.
Transitioning from epoprostenol requires careful dose adjustment.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

infusion site painheadachediarrheanauseajaw painhypotension

Serious

severe infusion site reactionsinfections
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Warnings

⚠ Important warnings

  • Avoid abrupt stopping of the infusion.
  • Use caution in patients with liver issues.
  • Monitor for infections with intravenous use.
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Drug interactions

  • Gemfibrozilincreases treprostinil levelsMonitor
  • Rifampindecreases treprostinil levels.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).