MedDataToolSympazan is a medication used to help control seizures in people aged 2 years and older who have Lennox-Gastaut Syndrome. It works by enhancing the effects of a natural calming substance in the brain, which helps reduce seizure activity. The medication comes in the form of oral films that dissolve on the tongue and is typically started at a dose of 5 mg daily for patients weighing 30 kg or less, or 10 mg daily for those over 30 kg, with a maximum dose of 20 mg or 40 mg daily, respectively. It's important to know that Sympazan should not be taken if you have a history of allergic reactions to it or its ingredients. Additionally, if you take strong medications that affect liver enzymes, like ketoconazole, your doctor may need to adjust your dose of Sympazan.
✦
Uses
- Seizures associated with Lennox-Gastaut Syndrome in patients 2 years and older.
◷
Dosage
For patients weighing 30 kg or less: Start at 5 mg daily, increase to 20 mg daily as tolerated.
For patients weighing more than 30 kg: Start at 10 mg daily, increase to 40 mg daily as tolerated.
For doses above 5 mg/day, take in two divided doses.
Can be taken with or without food, but do not take with liquids.
Always follow your doctor's specific instructions for your dose.
⚠
Side effects
Common
Common side effects include constipationsedationlethargydroolingand fever
Serious
Serious side effects include dependencewithdrawal reactionsand suicidal behavior
🛑
Warnings
⚠ Important warnings
- Risk of severe sedation and respiratory depression when used with opioids.
- Potential for abuse, misuse, and addiction.
- Withdrawal can be life-threatening; taper off gradually.
- Use caution in elderly patients and those with liver impairment.
⇄
Drug interactions
- Alcoholincreases clobazam levels by 50%Monitor
- Opioidsincreases risk of respiratory depressionMonitor
- CYP2D6 drugsmay require lower dosesCaution
- Strong or moderate CYP2C19 inhibitorsmay need dosage adjustmentCaution
- Cannabidiolincreases risk of adverse reactions.Monitor
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).