MedDataToolSynjardy Xr
Generic: Empagliflozin, Metformin Hydrochloride
SGLT2 inhibitor✓ FDA-verified
View full FDA label ↗Synjardy XR is a medication used to help manage blood sugar levels in adults with type 2 diabetes, especially when diet and exercise alone are not enough. It combines two ingredients that work together: one helps your body get rid of excess sugar through urine, while the other improves how your body uses insulin and lowers sugar production in the liver. You take it as a tablet once a day with a meal, starting with a dose of 10 mg of empagliflozin and up to a maximum of 25 mg, along with 2,000 mg of metformin. It's important to know that this medication is not recommended for people with severe kidney problems, as it can cause serious side effects. Additionally, if you take insulin or certain other diabetes medications, you may have a higher risk of low blood sugar while using this medication.
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Uses
- Type 2 diabetes mellitus in adults.
- Type 2 diabetes mellitus in pediatric patients aged 10 years and older.
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Dosage
Adults: Take SYNJARDY twice daily with meals.
Adults: Take SYNJARDY XR once daily with a meal in the morning.
Pediatric patients: Take SYNJARDY twice daily with meals.
Maximum dose: 25 mg of empagliflozin and 2000 mg of metformin HCl.
Not recommended for patients with eGFR less than 45 mL/min/1.73 m².
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Urinary tract infectionsfemale genital infectionsDiarrheanauseavomitingflatulenceabdominal discomfortLactic acidosisGenital infectionslower limb amputationhypersensitivity reactions
Serious
diabetic ketoacidosisvolume depletion
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Warnings
⚠ Important warnings
- Not for type 1 diabetes; risk of diabetic ketoacidosis.
- Not recommended for patients with eGFR less than 30 mL/min/1.73 m².
- Risk of lactic acidosis, especially in renal impairment.
- Monitor renal function and volume status before starting.
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Drug interactions
- Topiramatemay increase risk of lactic acidosisCaution
- Cimetidinemay increase risk of lactic acidosisCaution
- Alcoholmay enhance metformin's effect on lactate metabolismCaution
- Diureticsmay increase urine volume and risk of volume depletionCaution
- Insulinmay increase risk of hypoglycemia.Caution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).