MedDataToolTolsura is a medication used to treat certain serious fungal infections, including blastomycosis, histoplasmosis, and aspergillosis, in both immunocompromised and non-immunocompromised adults. It works by stopping the growth of fungi in the body. You take it as capsules, swallowing them whole with food, starting at a dose of 130 mg once daily, which can be increased to a maximum of 260 mg per day if needed. It's important to know that Tolsura should not be taken if you are allergic to itraconazole, the active ingredient in the medication. Additionally, you should avoid taking it with certain medications, like colchicine, as this can lead to serious side effects.
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Uses
- Blastomycosis.
- Pulmonary Histoplasmosis.
- Extrapulmonary Histoplasmosis.
- Aspergillosis.
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Dosage
130 mg (2 × 65 mg capsules) once daily for Blastomycosis and Histoplasmosis.
Increase to 260 mg/day if no improvement, given in two doses.. 130 mg (2 × 65 mg capsules) once daily for Aspergillosis.
In life-threatening situations, start with 390 mg/day for 3 days, then adjust.
TOLSURA must be taken with food and capsules should be swallowed whole.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nausearashvomitingedemaheadachediarrhea
Serious
congestive heart failurehepatotoxicitycardiac dysrhythmiashearing loss
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Warnings
⚠ Important warnings
- Can cause or worsen congestive heart failure.
- Not for treating onychomycosis.
- Not interchangeable with other itraconazole products.
- Avoid certain drugs that affect CYP3A4 metabolism.
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Drug interactions
- Colchicinecontraindicated in renal or hepatic impairmentAvoid
- Fesoterodinecontraindicated in renal or hepatic impairmentAvoid
- Solifenacincontraindicated in severe renal or moderate to severe hepatic impairmentAvoid
- Methadonecontraindicated during and 2 weeks after TOLSURA treatmentAvoid
- Alfuzosinnot recommended during and 2 weeks after TOLSURA treatment.Caution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).