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Trifluoperazine

Generic: Trifluoperazine Hydrochloride

Rx only
Antipsychotic✓ FDA-verified
View full FDA label ↗
Trifluoperazine is a medication used to treat schizophrenia and can also help with short-term anxiety, although it's not usually the first choice for anxiety treatment. It works by affecting certain chemicals in the brain to help improve mood and reduce symptoms. You typically start with a dose of 2 to 5 mg taken twice a day, and the maximum dose for anxiety is 6 mg per day, while for schizophrenia, it can be increased to 40 mg daily if needed. It's important to know that this medication can cause serious side effects like tardive dyskinesia, which involves involuntary movements that may not go away even after stopping the drug. Additionally, if you are taking other central nervous system depressants, like sedatives or alcohol, you should be cautious, as they can increase the sedative effects of trifluoperazine.

Uses

  • Schizophrenia.
  • Generalized non-psychotic anxiety.

Dosage

Adults: 1 or 2 mg twice daily for anxiety, not exceeding 6 mg per day for 12 weeks.
Adults: Starting dosage for psychotic disorders is 2 mg to 5 mg twice daily.
Children (ages 6 to 12): Starting dosage is 1 mg once daily or twice daily, may increase gradually.

Side effects

Common

Drowsinessdizzinessdry mouthblurred visionRashinsomniafatiguemuscular weaknessTardive dyskinesia

Serious

neuroleptic malignant syndromeextrapyramidal symptoms
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Warnings

⚠ Important warnings

  • Increased risk of death in elderly patients with dementia-related psychosis.
  • Risk of tardive dyskinesia with long-term use.
  • Not approved for treating dementia-related psychosis.
  • May impair mental and physical abilities, caution with activities requiring alertness.

Drug interactions

  • Sedativesincreased risk of sedationMonitor
  • Narcoticsincreased risk of sedationMonitor
  • Alcoholincreased risk of sedation.Monitor

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).