MedDataToolValtoco is a nasal spray used to treat sudden episodes of frequent seizures, known as seizure clusters, in people with epilepsy who are at least 2 years old. It works by enhancing the effects of a natural calming chemical in the brain, helping to reduce seizure activity. The starting dose is based on the patient's age and weight, typically ranging from 5 mg to 20 mg, and it can be given as a single spray into one or both nostrils. You should not use it more than twice for a single seizure episode and not more than five times in a month. It's important to know that Valtoco should not be used if you have a known allergy to diazepam, and it can interact with opioids, which may increase the risk of serious side effects.
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Uses
- Acute treatment of seizure clusters.
- Acute repetitive seizures in epilepsy patients aged 2 years and older.
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Dosage
Administer VALTOCO by nasal spray only.
Initial dose is 5 mg or 10 mg as a single spray in one nostril.
For 15 mg and 20 mg doses, use two sprays, one in each nostril.
A second dose may be given at least 4 hours after the first if needed.
Do not exceed 2 doses for a single episode, and limit to one episode every five days.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
somnolenceheadachenasal discomfortrisk of respiratory depression
Serious
dependencewithdrawal reactions
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Warnings
⚠ Important warnings
- Risk of severe sedation when used with opioids.
- Potential for abuse, misuse, and addiction.
- Dependence may occur with frequent use.
- Withdrawal can be life-threatening if stopped suddenly.
- Use caution in patients with liver impairment.
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Drug interactions
- Opioidsincreased risk of respiratory depressionMonitor
- CNS depressantsenhanced sedative effectsCaution
- CYP2C19 inhibitorsincreased adverse reactionsCaution
- CYP3A4 inhibitorsincreased adverse reactionsCaution
- CYP2C19 inducersdecreased effectivenessCaution
- CYP3A4 inducersdecreased effectiveness.Caution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).