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Versacloz

Generic: Clozapine

Rx only
Atypical antipsychotic✓ FDA-verified
View full FDA label ↗
Versacloz is a medication used to treat severe schizophrenia in patients who haven't responded well to other treatments and to help reduce the risk of suicidal behavior in certain patients with schizophrenia or schizoaffective disorder. It works by affecting certain brain chemicals to help improve mood and thoughts. You take it as an oral suspension, starting with a dose of 12.5 mg once or twice daily, which can be increased to a maximum of 450 mg twice daily based on how well you tolerate it. A key warning is that it can cause a serious drop in white blood cell count, so regular blood tests are necessary to monitor this. Additionally, if you're taking strong medications that affect liver enzymes, like fluvoxamine, your doctor may need to adjust your Versacloz dose.
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Uses

  • Treatment-resistant schizophrenia.
  • Reducing risk of suicidal behavior in schizophrenia.
  • Reducing risk of suicidal behavior in schizoaffective disorder.
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Dosage

Start with 12.5 mg once or twice daily.
Increase to 150–225 mg twice daily over two weeks.
Maximum dose is 450 mg twice daily.
Can be taken with or without food.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

sedationdizzinessheadachetremorconstipationnausea

Serious

severe neutropeniaseizuresmyocarditiscardiomyopathyincreased mortality in elderly
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Warnings

⚠ Important warnings

  • Can cause severe neutropenia leading to serious infections.
  • Risk of orthostatic hypotension, bradycardia, and syncope.
  • Seizures may occur, especially at higher doses.
  • Risk of myocarditis and cardiomyopathy.
  • Not approved for elderly patients with dementia-related psychosis.
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Drug interactions

  • Fluvoxaminereduce VERSACLOZ dose to one thirdCaution
  • Ciprofloxacinreduce VERSACLOZ dose to one thirdCaution
  • Enoxacinreduce VERSACLOZ dose to one thirdCaution
  • Tobacco smokemay decrease VERSACLOZ effectivenessCaution
  • Anticholinergic drugsmay increase risk of toxicity.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).