MedDataToolVfend is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis and candidemia. It works by stopping the growth of fungi in the body. You can take it either as an intravenous infusion or in oral forms, with a typical starting dose of 6 mg/kg every 12 hours for the first day, followed by a maintenance dose of 4 mg/kg every 12 hours, but the maximum dose can vary based on your specific needs. It's important to know that Vfend can cause liver problems, so your doctor will monitor your liver function while you are on this medication. Additionally, if you are taking phenytoin, a medication used for seizures, it may affect how Vfend works, so your doctor will need to adjust your doses accordingly.
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Uses
- Invasive aspergillosis.
- Candidemia in non-neutropenic patients.
- Deep tissue Candida infections.
- Esophageal candidiasis.
- Serious fungal infections from Scedosporium and Fusarium species.
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Dosage
Adults: 6 mg/kg every 12 hours for invasive aspergillosis.
Adults: 200 mg every 12 hours for candidemia.
Pediatric patients 2 to less than 12 years: 9 mg/kg every 12 hours for invasive aspergillosis.
Pediatric patients: 4 mg/kg every 12 hours for candidemia.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
visual disturbancesfevernausearashvomiting
Serious
hepatic toxicityarrhythmiassevere skin reactionsrenal toxicity
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Warnings
⚠ Important warnings
- Monitor liver function tests during treatment.
- Contraindicated with rifampin and high-dose ritonavir.
- Use caution in patients with liver or kidney impairment.
- May cause serious visual disturbances.
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Drug interactions
- Rifampinsignificantly reduces voriconazole effectivenessCaution
- Efavirenzreduces voriconazole effectivenessCaution
- Phenytoinreduces voriconazole effectivenessCaution
- Fluconazoleincreases voriconazole levelsMonitor
- John's Wortsignificantly reduces voriconazole effectivenessCaution
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Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).