MedDataToolWarfarin is a medication used to prevent and treat blood clots, such as those caused by deep vein thrombosis or pulmonary embolism, and to reduce the risk of stroke in people with certain heart conditions. It works by blocking the action of vitamin K, which is necessary for the body to make blood-clotting factors. The medication is taken as a tablet, usually starting at a dose of 2 to 5 mg once daily, with typical maintenance doses ranging from 2 to 10 mg daily. It's very important to note that warfarin should not be used during pregnancy due to the risk of harm to the fetus. Additionally, if you are taking heparin, a common blood thinner, it can affect how warfarin works, so close monitoring of your blood levels is necessary.
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Uses
- Venous thrombosis.
- Pulmonary embolism.
- Atrial fibrillation complications.
- Cardiac valve replacement complications.
- Reduction of death and recurrent myocardial infarction.
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Dosage
Individualized dosing based on INR response.
Target INR of 2 to 3 for most conditions.
Monitor INR daily until stable, then every 1 to 4 weeks.
Initial dose usually 2 to 5 mg once daily.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nauseavomitingdiarrheaabdominal painrashmajor bleeding
Serious
tissue necrosisacute kidney injury
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Warnings
⚠ Important warnings
- Risk of major or fatal bleeding.
- Regular INR monitoring is necessary.
- Certain drugs and dietary changes can affect INR.
- Use caution in elderly patients and those with renal impairment.
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Drug interactions
- Heparinincreases INR effectMonitor
- Aspirinincreases bleeding riskMonitor
- Antibioticsmay affect INR levelsCaution
- Antifungalsmay affect INR levelsCaution
- Ginkgo bilobamay increase bleeding risk.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).